The World Health Organisation says it's theoretically possible to wipe out malaria, but probably not with the imperfect vaccine and other control methods being used at the moment.
Dr. Pedro Alonso, the UN health agency's global malaria director, said WHO is "unequivocally in favour" of eradication, but that major questions about its feasibility remain.
In a press briefing on Thursday, Alonso acknowledged that "with the tools we have today, it is most unlikely eradication will be achieved".
Alonso was presenting the results of a WHO-commissioned report evaluating if eradicating malaria should be pursued.
He said the experts concluded lingering uncertainties meant they were unable to formulate a clear strategy and thus, couldn't propose a definitive timeline or cost estimate for eradication.
WHO has long grappled with the idea of erasing malaria from the planet. An eradication campaign was first attempted in 1955 before being abandoned more than a dozen years later.
For decades, health officials were chastened from even discussing eradication - until the Bill and Melinda Gates Foundation threw its considerable resources behind the idea.
Smallpox is the only human disease to ever have been eradicated. In 1988, WHO and partners began a global campaign that aimed to wipe out polio by 2000.
Despite numerous effective vaccines and billions of invested dollars, efforts have stalled in recent years and officials have repeatedly missed eradication targets.
Although several African countries began immunising children against malaria in national programs this year, the shot only protects about one third of children who get it.
The parasitic disease kills about 435,000 people every year, mostly children in Africa.
"An effective vaccine is something we desperately need if we're ever going to get malaria under control and we just don't have it," said Alister Craig, dean of biological sciences at the Liverpool School of Tropical Medicine.
A previous trial showed the vaccine was about 30 per cent effective in children who got four doses, but that protection waned over time.
Craig also raised concerns about whether malaria programs would be able to raise the billions needed given other competing eradication campaigns, like those for polio, guinea worm and lymphatic filariasis.
"Should we really be pushing for malaria or should we concentrate on getting some of those other diseases out of the way first?" he asked.
Australian Associated Press